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The Bug Butcher, recently released on Steam, tasks players with dealing with an alien insect infestation aboard a space station. Space bugs can be eliminated using a variety of available weapons, with players able to use rockets, lasers, bullets, and lightning to complete their exterminations.
Harry, the main character, has a very specific handicap in that he can only shoot directly overhead, but a second player can enter the game in co-op should the overhead threats prove too challenging for one person alone.
The Bug Butcher is heavily inspired by Super Pang (which is currently getting an HD revival as Pang Adventures).